CORDIS Project
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This project investigates how metabolites, specifically acyl-CoAs, influence gene regulation through posttranslational modifications on histones. It focuses on the role of YEATS-reader proteins in cancer, aiming to elucidate their mechanisms and interactions with metabolic proteins to uncover new therapeutic strategies…
Metabolism and gene regulations act in concert to shape cellular identity and plasticity.
One major line of crosstalk occurs through metabolites such as acyl-CoAs, which are inscribed on histones as posttranslational modifications (PTMs) to be subsequently recognised by reader proteins, resulting in initiation of specific transcriptional programs.
The increasing identification of novel PTMs necessitates thorough characterisation, however still remain largely underexplored.
For instance, the pres…
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