CORDIS Project
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This project investigates how the structure of messenger RNA (mRNA) influences its interactions with RNA-binding proteins, which are crucial for gene expression regulation. It aims to understand the role of N6-methyladenosine modifications in these interactions, particularly in relation to diseases like cancer and obes…
In the current paradigm of gene expression, the structure of messenger RNA (mRNA) is a key element of posttranscriptional control because it modulates interactions with RNA-binding proteins (RBPs). RBPs typically recognize RNA-binding domains to form ribonucleoprotein complexes that ‘commit’ mRNAs to specific functions, and mutated or deregulated RBPs are implicated in multiple neurodegenerative diseases and cancer.
Yet, the knowledge on the dynamic regulation of ribonucleoprotein complexes in m…
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