CORDIS Project
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This project explores the self-renewal capabilities of tissue-resident macrophages, focusing on how aging affects their function and regeneration. It aims to identify molecular pathways that could rejuvenate macrophages to enhance tissue integrity and immune response.
Tissue resident macrophages are essentially present in every organ of the body and perform critical functions in immunity,tissue homeostasis and regeneration.
Recent evidence shows that resident macrophages can originate from embryonicprogenitors and be maintained in tissues long term by local proliferation independently of monocytes.
This self-renewalability, however, appears to decline with age, with potentially major consequences for the response to infection, theresolution of inflammation an…
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