CORDIS Project
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This project investigates the roles of specific protein modules that bind to ADP-ribose derivatives, focusing on their implications in DNA repair and disease. The aim is to uncover mechanisms of cellular processes regulated by these proteins to inform the development of new therapeutic drugs.
The macrodomain is a ubiquitous protein module known to bind to ADP-ribose derivatives, which diverged through evolution to support protein functions involved in DNA repair and the maintenance of genomic stability, transcriptional regulation, cell signaling, telomere dynamics, necrosis and apoptosis.
Derivatives of ADP-ribose are synthesized by NAD+-dependent protein modification enzymes poly(ADP-ribose) polymerases (PARPs) and NAD+-dependent protein deacetylases (sirtuins). PARPs attracted enor…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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United Kingdom, Manchester
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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