CORDIS Project
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This project aims to understand the role of chromatin modifications in gene regulation by using advanced genomic tools. It focuses on the causal effects of specific chromatin marks on transcription, potentially leading to new therapeutic strategies for gene expression control.
Chromatin modifications are essential for the transcriptional programmes underpinning development and cellular identity.
However, an understanding of the causal function(s) of chromatin marks in gene regulation has lagged behind.
Particularly, whether chromatin modifications linked with active transcription (active marks) have a causal function remains intensely debated, while the underlying mechanisms are poorly understood.
This is due to technical limitations in the ability to precisely pertur…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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