CORDIS Project
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This project explores the relationship between stem cell functionality and aging using the model organism Macrostomum lignano. It aims to understand the molecular mechanisms of rejuvenation and develop genetic tools to study stem cell behavior and lifespan extension.
The ‘stem-cell theory’ of ageing posits that the functional decline in adult stem cells is one of the factors contributing to ageing.
Importantly, the number of stem cells does not diminish with age in many tissues but rather there are intrinsic and extrinsic changes that affect their functionality.
Is it possible to reverse these changes?
Experiments in the emerging model Macrostomum lignano suggest that this is indeed the case.
Remarkably, induced regeneration in this animal leads to extended…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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