CORDIS Project
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MACROCODE investigates the genetic regulation of macrophages during chronic inflammation, aiming to understand their altered functions. By using advanced gene editing and computational methods, the project seeks to identify key genes that drive macrophage behavior in inflammatory diseases.
Macrophages are essential cells of the innate immune system, playing crucial roles in coordinating inflammatory responses and maintaining homeostasis.
In cases of chronic inflammation, damaged tissues release abnormal signals that attract macrophages precursors to the local environment and drive macrophages toward a proinflammatory phenotype.
This creates a feedback loop that sustains inflammation.
The consequences to society are huge: chronic inflammatory diseases are among the leading causes o…
GENOME RESEARCH LIMITED
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