CORDIS Project
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This project investigates the role of macrophages in atherosclerosis, focusing on their origins and functions within plaques. Using a novel mouse model, it aims to differentiate between macrophages derived from local proliferation and those from monocyte recruitment, ultimately seeking to inform targeted therapies for…
Atherosclerosis is a slowly progressing inflammatory disease that underlies some of the most common causes of death in western society.
The central role of macrophages throughout its pathogenesis makes this cell an eminent target for therapeutic intervention.
Recent studies have subverted the classical view that atherosclerotic plaque macrophages mainly originate from recruited circulating monocytes, launching the new notion that macrophages could also be derived from clonal expansion of residen…
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