CORDIS Project
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This project investigates the role of specific transcription factors, Egr1 and Egr2, in macrophage function and their impact on inflammatory diseases like atherosclerosis. By understanding how these factors regulate enhancer activity, the research aims to identify potential therapeutic targets for managing macrophage-d…
Macrophages play important roles in many aspects of immunity and therefore contribute to a diverse range of human inflammatory diseases, including atherosclerosis.
The expression of macrophage genes is tightly controlled by regulatory DNA elements, such as enhancers.
When macrophages are exposed to external stimuli, specific transcription factors affect enhancer activity, thereby impacting macrophage function in health and disease.I am investigating macrophage enhancer activation by interleukin-…
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