CORDIS Project
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This project investigates the role of adipose tissue macrophages in the progression of non-alcoholic steatohepatitis to liver fibrosis. By analyzing both mouse models and human biopsies, it aims to uncover the immunological mechanisms driving liver inflammation and fibrosis, potentially leading to new therapeutic targe…
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and damage.
This drives liver inflammation, promoting the progression to non-alcoholic steatohepatitis (NASH) and liver fibrosis.
There are currently no approved therapies for NASH and fibrosis, which is in part due to a lack of knowledge of the immunological events underpinning NASH and fibrosis.
The pathogenesis of NASH is strongly influenced by crosstalk with other tissues.
There is increasing evidence that specif…
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