CORDIS Project
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This project focuses on understanding the regulation of messenger RNA through various cap structures, including newly discovered non-canonical caps. The goal is to develop a method for sequencing these caps alongside their RNA transcripts to explore their functions and the broader regulatory mechanisms involved in gene…
From their creation to their degradation, mRNAs are under extensive regulation.
This regulation is directed not only by their nucleotide sequence and their promoter but also by post- and co-transcriptional modifications attached to the RNA.
One of the most ubiquitous of these modifications in eukaryotes is the 5' cap typically a methylated guanine (m7G) attached inversely to the first transcribed nucleotide.
Several decades of research have revealed the m7G cap as an interface for regulating st…
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