CORDIS Project
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This project aims to uncover the mechanisms behind the adverse effects of beta2 agonists used in asthma treatment. It investigates how these medications interact with respiratory cells and the impact of inhaled corticosteroids on inflammation and asthma exacerbations.
Beta2 agonists (B2as) such as the short acting salbutamol, used to relieve acute wheeze, and the long acting salmeterol used to control asthma with inhaled steroids (ICS), are almost universally used in asthma.
However, there is significant concern over morbidity and mortality related to adverse effects, particularly when used without ICS, and/or in excess at exacerbation (mostly caused by rhinovirus [RV] infection).
The mechanisms of adverse effects are not understood.
This proposal will rock t…
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