CORDIS Project
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This project investigates Mucosal Associated Invariant T cells (MAITs), a type of immune cell that interacts with gut microbiota. Using a new mouse model, the project aims to understand MAITs' development and their role in health and disease, particularly in relation to gut microbiome changes.
Mucosal Associated Invariant T cells (MAITs) represent an evolutionary conserved subset that express a semi-invariant TCR recognizing a new class of microbial metabolite antigens presented by the MHC class Ib molecule, MR1.
In addition to their wide anti-microbial specificity, the high inter-species conservation of both MR1 and invariant TCR infers an important biological role for MAITs. MAITs are abundant in human blood (1-8 % of T cells), mucosa and liver (20-50%).
After development in the thy…
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