CORDIS Project
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This project studies Mucosal Associated Invariant T cells (MAITs) to understand their role in tissue repair and immune response during infections. It aims to uncover how environmental factors influence MAIT functions in skin and lung tissues.
Mucosal associated invariant T cells (MAITs) represent an abundant subset in humans with unique specificity for microbial metabolites. MAIT conservation along evolution indicates important, non-redundant functions.
Despite changes in MAIT frequency and phenotype in several infectious and non-infectious diseases, their functions are still unclear.
By contrast with mainstream CD4+ or CD8+ T cells, MAITs differentiate into effector cells during thymic development.
How the differentiation program i…
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