CORDIS Project
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This project aims to uncover the mechanisms regulating the development and tissue colonization of mucosal-associated invariant T cells. By using advanced genetic techniques, it seeks to identify factors that influence these immune cells' maturation and their role in maintaining tissue health.
Mucosal-associated invariant T (MAIT) cells colonize mucosal tissues where they become tissue-resident and have important protective and homeostatic functions. MAIT cells are selected in the thymus by microbial metabolites presented by MHC-related protein 1 (MR1) on thymocytes thereby acquiring an effector phenotype (type 1 or 17).
This project aims at elucidating mechanisms that regulate the last stages of thymic MAIT cell development, including their egress, and identify cues necessary for tis…
INSTITUT CURIE
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