CORDIS Project
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This project develops advanced 3D in vitro models to study the blood-brain barrier in humans and macaques infected with malaria. It aims to understand the distinct pathogenic mechanisms of Plasmodium falciparum and Plasmodium knowlesi, focusing on cytoadhesion and blood-brain barrier disruption.
Plasmodium falciparum cerebral malaria (CM) is the most severe complication during malaria infections. CM is associated with patient coma and blood-brain barrier (BBB) disruption resulting in brain swelling and patient death.
In the zoonotic malaria parasite P. knowlesi, CM is described in rhesus macaques but occurs neither in human infections nor in the natural long-tail macaque reservoir.
Infected red blood cell cytoadhesion to endothelial cells and the release of parasite toxins have been des…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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