CORDIS Project
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This project investigates the molecular mechanisms of sexual reproduction in Plasmodium parasites, which cause malaria. By identifying key genes involved in sex determination, it aims to enhance understanding of parasite transmission and develop new interventions to combat malaria.
Sexual reproduction is an obligate stage in the complex life cycle of Plasmodium parasites, the causative agent of malaria.
While cyclic asexual replication of the parasite in the vertebrate host is associated with all clinical symptoms of malaria, transmission of the disease to a new host relies on sexual reproduction of the parasite in the mosquito.
Transmission and reproductive success depend on the ability of malaria parasites to produce fertile male and female gametes at an optimal ratio. H…
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