CORDIS Project
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This project investigates the mechanisms of drug resistance in the malaria parasite Plasmodium falciparum, focusing on how it internalizes hemoglobin during its lifecycle. By studying the role of specific proteins, particularly Kelch13, the research aims to understand endocytosis and identify potential strategies to ov…
Blood stages of the protozoan parasite Plasmodium falciparum are responsible for malaria, a disease that kills more than 400'000 people annually.
During its development in red blood cells the parasite internalises a large part of the host cell cytosol (hemoglobin) in an endocytic process and digests it in its food vacuole.
We recently identified a critical connection of this hemoglobin endocytosis with resistance of the parasite to the current frontline drug Artemisinin, revealing the mechanism…
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
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