CORDIS Project
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The MALBENA project investigates how beta-adrenergic receptor stimulation affects the voltage-gated sodium channel, Nav1.5, in heart cells. By understanding these mechanisms in both healthy and failing hearts, the project aims to develop targeted therapies for cardiovascular diseases with minimal side effects.
Cardiovascular disease is a leading cause of morbidity and mortality in Europe and, in the face of population aging, this statistic is predicted to significantly worsen.
One of the major CVD risk factors is represented by the alterations of beta-adrenergic receptors stimulation, which modulates the function of the voltage-gated sodium channel, Nav1.5, in cardiomyocytes.
In a healthy heart, beta-adrenergic receptors regulate the function of Nav1.5 to potentiate cardiac contraction during common e…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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