CORDIS Project
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This project investigates the relationship between endoplasmic reticulum stress, mitochondrial dysfunction, and insulin resistance in mouse models. It aims to understand how alterations in the communication between these organelles affect metabolic processes and contribute to insulin resistance, with a focus on develop…
The high calory intake and the sedentary behaviours represent one of the most common stress to which humanity is subjected.
This is leading to an increased incidence of obesity that can be aggravated by dysfunctional metabolism, among which insulin resistance (IR) is the most common scenario.
Two crucial processes know to lead to IR are Endoplasmic Reticulum (ER) stress and mitochondrial dysfunction.
Mitochondria and ER are in tight physical contact through the mitochondria-associated ER membran…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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