CORDIS Project
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This project explores the mechanisms of amyloid-like protein aggregation, focusing on how specific amino acid interactions influence aggregation specificity and cross-seeding. It aims to develop predictive algorithms for understanding co-aggregation in diseases such as neurodegenerative disorders and cancer.
Amyloid-like protein aggregation is a process of protein assembly via the formation of intermolecular β-structures by short aggregation prone sequence regions.
This occurs as an unwanted side-reaction of impaired protein folding in disease, but also for the construction of natural nanomaterials.
Aggregates appear to be strongly enriched in particular proteins, suggesting that the assembly process itself is specific, but the cross-seeding of the aggregation of one protein by aggregates of another…
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