CORDIS Project
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This research explores the role of specific DNA modifications in motor neuron disorders, focusing on the relationship between DNA methylation and gene expression. It aims to identify therapeutic targets for conditions like Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis.
Motor neuron disorders (MND) are a spectrum of devastating diseases caused by motor neuron (MN) cell death.
Recent findings revealed that DNA methylation is a hallmark of MN cell death.
However, the cause and affected mechanisms leading to methylation increase remain mostly unknown, therefore limiting the design of therapeutic intervention.
The discovery of a novel DNA modification has provided a paradigm shift in the understanding of DNA methylation and demethylation regulatory network.
In fact…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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