CORDIS Project
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The project aims to enhance microbial production processes through metabolic engineering by mapping interactions between metabolites and proteins in Escherichia coli. By identifying regulatory relationships, it seeks to optimize strains for efficient production of succinic acid, a valuable chemical for various industri…
Metabolic engineering creates improved microbes for industrial biotechnology.
Rational design of industrial microbes centres on modifications of genes with known roles in the production pathway of interest.
However, genes that are unrelated to the production pathway are also known to substantially impact productivity.
To date there are no methods that allow the prediction of such distal genes on a rational basis.
Effects of distal genes are indirect, and mediated through regulatory interactions…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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