CORDIS Project
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This project investigates the role of PIWI interacting RNAs in the interaction between arboviruses and their mosquito vectors, particularly focusing on chikungunya virus. By employing molecular virology and RNA sequencing, it aims to understand how these small RNA molecules influence viral persistence and transmission…
Mosquitoes transmit several medically and economically important ARthropod-BOrne (arbo)viruses to mammals (including humans), such as dengue virus and chikungunya virus (CHIKV).
Unlike infection in their mammalian host, infection in their arthropod vector is apathogenic and persistent due to the interplay between the virus and the innate immune responses.
The main antiviral mechanism in mosquitoes is the sequence specific RNA break down mechanism- RNA interference (RNAi), specifically the 21 nuc…
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