CORDIS Project
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This project focuses on hepatitis C virus (HCV) and aims to elucidate the role of a specific viral protein in the replication process and its impact on liver cell transformation. The goal is to better understand the mechanisms that lead to chronic liver disease.
Over 150 million individuals are infected with hepatitis C virus (HCV) worldwide. HCV is involved in chronic liver inflammation, fibrosis and formation of liver tumors.
Similarly to other positive strand RNA viruses, HCV is believed to replicate its genome in association with cytoplasmic membranes.
Nevertheless, the mechanisms of assembly and maintenance of the RNA replication complex as well as the mechanisms of cell transformation remain largely unknown.
While previously characterized by a com…
BAR ILAN UNIVERSITY
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