CORDIS Project
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This project investigates the role of smooth muscle cells in resolving inflammation related to atherosclerotic cardiovascular disease. It focuses on the signaling mechanisms of maresin 1 and its receptor LGR6, aiming to understand how they can aid in plaque stabilization and inflammation resolution.
Atherosclerotic cardiovascular disease (ASCVD) is a progressive disease characterized by aberrant immune activation and chronic vascular inflammation as a result from a failure in the resolution phase.
However, the mechanisms responsible for this dysregulation are not well understood.
Little is known about the role of smooth muscle cells (SMCs) in regulating resolution of inflammation, an active process orchestrated by endogenous specialized proresolving lipid mediators (SPMs).
These include the…
KAROLINSKA INSTITUTET
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