CORDIS Project
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This project investigates the SHP2 protein's role in signaling pathways related to Noonan syndrome and leukemia. It aims to understand how mutations affect SHP2 function and to design inhibitors that could lead to new treatments.
SHP2 is an SH2 domain-containing protein tyrosine phosphatase with a key role in the RAS-MAPK signaling pathway.
Germline mutations in PTPN11, the gene encoding SHP2, occur in 50% of individuals affected by Noonan syndrome, whereas somatic mutations in this gene cause more than 30% of cases of juvenile myelomonocytic leukemia (JMML), and are more rarely found in other hematologic malignancies and tumors.The X-ray structure of SHP2 shows a multidomain architecture compatible with an allosteric re…
GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
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