CORDIS Project
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This project focuses on developing methods to analyze genetic variants associated with cardiometabolic traits, particularly rare variants. It aims to create a software tool for multi-phenotype analysis and conduct large-scale studies to understand the genetic architecture of these traits.
The obesity rates are rapidly increasing worldwide concomitantly with rising prevalence of chronic diseases, including cardiovascular disease and type 2 diabetes.
Individual trait genome-wide association studies of common variants (minor allele frequency, MAF>5%) have highlighted complex genetic relationships between related cardiometabolic phenotypes with an intriguing pattern of associated overlapping DNA sequence variant effects, which does not always follow the epidemiological correlations.…
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