CORDIS Project
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This project focuses on the role of voltage-gated sodium channels in chronic pain, particularly the Nav1.7 subtype. It aims to develop specific chemical probes to study these channels and identify potential pain relief treatments.
Chronic pain represents a major unmet medical need which has been linked to changes in voltage-gated sodium channels (VGSCs).
These channels are transmembrane protein-complexes with a key-role in signal transmission in excitable cells, such as neurons, and allow the flux of Na+ ions through the cellular membrane in response to specific stimuli, thus controlling the generation and propagation of action potentials.
Nine VGSC subtypes are known to be expressed in different cell types, and among the…
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