CORDIS Project
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This project investigates the role of the matricellular protein hevin in stress resilience and depression-like behaviors. By manipulating hevin expression in specific brain cells, the research aims to uncover its impact on neuroplasticity and emotional responses, potentially informing treatments for psychiatric disorde…
Matricellular proteins mediate interaction between cells and the extracellular matrix and are essential regulators of synaptic function and architecture.
Recently, the two prototypical matricellular proteins SPARC and hevin have been implicated in depression-like behaviors, antidepressant response and resilience to stress. I found that hevin is induced by chronic social stress in the nucleus accumbens (NAc), a key brain reward region, only in resilient individuals.
Importantly, its overexpressio…
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
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