CORDIS Project
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This research focuses on creating engineered biological systems capable of predictable functions. By utilizing cell-free systems derived from bacteria, the project aims to synthesize complex molecules, such as antiviral precursors, through a two-step strategy involving selective protein synthesis and hydrolysis.
The integration of orthogonality is a crucial research strategy in the rational design of biological systems for novel applications.
In order to produce such highly predictable orthogonal systems, we propose to employ cell-free systems of highly engineered composition generated from living cells, which are complex enough to reproduce the major synthetic capabilities of living cells - such as the synthesis of natural and artificial saccharides - but are simplified enough to come close to truly en…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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