CORDIS Project
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This project investigates G protein-coupled receptors, which are crucial for cell signaling and are targeted by many drugs. It aims to enhance our understanding of their dynamics in real time, potentially leading to improved therapies for various diseases.
G protein-coupled receptors (GPCRs) are the largest family of cell surface signal transducing proteins encoded by thehuman genome.
They allow the cell to respond to diverse array of extracellular signals, control most (patho)physiologicalprocesses, and are currently the therapeutic target of over 30% of marketed drugs.
However, GPCR drug discovery is stillcharacterised by a very high attrition rate, which reflects our inadequate understanding of the complex mechanisms ofGPCR signalling and regul…
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