CORDIS Project
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This project investigates the mechanisms behind the removal of differentiated cells from the intestinal epithelium, focusing on genetic factors and mechanical constraints. By analyzing gene expression and employing advanced imaging techniques, it aims to enhance understanding of tissue homeostasis in the intestine.
The intestinal epithelium undergoes continuous self-renewal through coordination of cell proliferation in the crypt and cell removal in the villus region.
The aim of this project is to elucidate the mechanisms controlling the removal of differentiated cells from the villus.
Preliminary data indicate that most extruding cells are non-apoptotic suggesting alternative mechanisms regulating this key homeostatic event.
Cells might either commit to extrusion through specific differentiation programs o…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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