CORDIS Project
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This project investigates the molecular interactions between beta-2 microglobulin and collagen to understand the formation of amyloid fibrils, which cause dialysis-related amyloidosis. It employs various biophysical techniques to explore these interactions and their implications.
β -2 microglobulin (β-2-m) is a 99 residue protein with an immunoglobulin fold. β-2-m is usually found as a part of the major histocompatibility 1 complex.
This protein aggregates to form amyloid fibrils in osteoarticular tissues, leading to pathological bone destruction and the condition known as dialysis-related amyloidosis (DRA).
The accumulation of β-2-m deposits has been shown to cause arthralgias, destructive osteoarthropaties and carpal tunnel syndrome.
The host laboratory has characteri…
UNIVERSITY OF LEEDS
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