CORDIS Project
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This project focuses on understanding the role of dendritic cells in cancer immunity, particularly how nutrient conditions affect their function. It aims to explore the relationship between energy sensing pathways and the immune response in melanoma, potentially leading to improved cancer treatment strategies.
BACKGROUND:
Dendritic cells (DC) are professional antigen presenting cells able to provide protective immunity to cancer. DC undergo functional maturation that can lead to tolerogenic phenotype associated with immune-suppression in cancer by a still unknown mechanism.
Recently the host laboratory revealed a new role of IKKβ/NF-kB signalling in the tolergenic function of DC.
However, the upstream regulators of this signalling and its implication in cancer have not yet been addressed.
Since malign…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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