CORDIS Project
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This project investigates the role of metabolic reprogramming in intestinal stem cells and its implications for colorectal cancer initiation and progression. By analyzing glucose metabolism, it aims to uncover critical steps in cancer development and potential therapeutic targets.
Metabolic reprogramming has recently emerged as a key hallmark of cancer.
Despite many efforts made to identify metabolic properties of cancer cells, there is a complete lack of understanding of the specific steps in the tumorigenic process when this metabolic rewiring occurs and its biological consequences.
In this regard, our previous work has revealed a critical role of glucose metabolism in driving tumor initiation, in particular in the intestine.
Importantly, recent studies have demonstrate…
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