CORDIS Project
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This project aims to create designer enzymes that can catalyze palladium-catalyzed cross-coupling reactions, which are not typically facilitated by natural enzymes. The focus is on developing hybrid catalysts and improving their efficiency through directed evolution.
Enzymes are remarkable catalysts.
The unmatched rate accelerations and exacting selectivities that these protein molecules achieve have whetted the appetite of chemists to harness the prowess of enzyme catalysis for industrial applications.
However, natural enzymes can only catalyze a small fraction of the reactions routinely employed by synthetic chemists.
As a result, creating designer biocatalysts with the ability to efficiently catalyze transformations not found in nature’s repertoire is a l…
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