CORDIS Project
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This project aims to develop a four-dimensional physical model of early mouse embryos to understand their cell dynamics during development. It focuses on the mechanical forces and cell interactions that shape the embryo, integrating theoretical modeling with experimental validation to uncover the principles of early ma…
The quantitative understanding of the early development of mammalian embryos is essential to the progress of reproductive medicine.
Yet, the physical and mechanical principles governing their morphogenesis remain largely unknown.
Early mouse embryos self-organize by a succession of cell divisions, deformations and rearrangements, leading ultimately to the specification of two distinct cell lineages, segregated in inside and outside layers.
Mechanical forces are therefore as important as biochemi…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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