CORDIS Project
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This project focuses on understanding leukocyte adhesion during immune responses using advanced force measurement techniques. By applying high-speed atomic force microscopy and acoustic force spectroscopy, it aims to explore the mechanics of white blood cells in response to inflammation.
Leukocytes, white blood cells, patrol the vascular wall of our vessels in search of sites of inflammation.
In the so-called leukocyte adhesion cascade, leukocytes flowing at high velocities (up to mm/s) impact the vessel wall, roll at µm/s, and finally migrate at nm/s to the site of inflammation.
They are thus subjected to mechanical forces from sub-msec to several minutes.
Complete understanding of the physical processes behind leukocyte adhesion requires an approach over multiple length and ti…
UNIVERSITE D'AIX MARSEILLE
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