CORDIS Project
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This project investigates how mechanical forces in the tumor microenvironment and blood flow impact breast cancer cell metastasis. By exploring the molecular mechanisms behind these interactions, the research aims to identify potential therapeutic targets to prevent the spread of cancer to secondary sites, particularly…
Mechanical abnormalities of the tumor microenvironment (TME) have gained much attention over the last decades as potent drivers of tumor progression.
These abnormalities include compressive forces that generate the so-called solid stress.
Solid stress is suggested to affect the metastatic potential of several tumor types, including breast cancer, however the exact molecular mechanisms involved remain to be explored.
Once cancer cells have left the primary tumor site and entered into the blood st…
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