CORDIS Project
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This project investigates the mechanical properties of intermediate filaments in human cells, aiming to understand how these proteins influence cell mechanics and function. By combining in vitro testing with cellular experiments, it seeks to establish a relationship between filament structure and cellular behavior duri…
The mechanical properties of each of the over 200 cell types in the human body are perfectly well adapted to their function.
The large variety of viscoelastic profiles, ranging from soft brain cells to stiff cartilage, and the temporal variability in the mechanical stress response when stationary cells begin to migrate, e.g. in embryogenesis, wound healing or cancer metastasis, is reflected in a surprisingly small number of molecular building blocks.
Three distinct filament systems, actin filame…
GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
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