CORDIS Project
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This project investigates the mechanical processes that ensure proper chromosome separation during cell division. By utilizing advanced imaging techniques in fruit flies, it aims to understand the forces involved in nuclear migration and how they are regulated during mitosis.
During mitosis the genetic material of the mother cell is separated and distributed between two daughter cells.
Responsible for this coordinated segregation is an assembly of polymers, molecular motors and adapter proteins– the mitotic spindle.
This super-molecular machine moves the chromosome halves in opposite directions over impressive cellular scales (tens of µm) within a relatively short time (minutes).
The regulatory biochemical pathways responsible for timing and error-control of mitosis…
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