CORDIS Project
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This project investigates the positioning of the centrosome in HeLa cells, focusing on the mechanical forces involved in its localization. By using laser ablation to manipulate microtubules, the research aims to clarify whether pushing or pulling forces dominate in centrosome positioning.
The Centrosome (CS) is an organelle located near the nucleus that constitutes the primary Microtubule Organization Center (MTOC) in animal cells.
The distribution of the microtubule cytoskeleton is therefore determined by the localization of the CS.
Localization of this organelle is important for many cellular processes:
I) Cell shape and polarization[6], II) Cell migration and III) Cell cycle.The processes underlying CS localization are mechanical, with two possible scenarios:
I) Pushing forces…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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