CORDIS Project
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This project investigates how DNA repairs itself through homologous recombination, focusing on the mechanisms by which a protein complex searches for matching DNA sequences. It aims to understand the efficiency and accuracy of this process, which is vital for maintaining genomic stability.
Homologous recombination is a mechanism by which DNA double-strand breaks are faithfully repaired using the sequence information present on an intact duplex DNA.
The efficiency of this mechanism is crucial for cell survival, and its accuracy is of prime importance for genomic stability.
Although being the signature reaction of homologous recombination, the search for homology performed by the broken molecule coated with the Rad51 recombinase (called the “nucleoprotein filament”) is poorly unders…
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