CORDIS Project
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This project investigates how microtubule plus end tracking proteins, particularly End Binding proteins, interact with microtubules and various cellular structures. By exploring the effects of anti-cancer compounds on these interactions, the project aims to develop new tools for visualizing microtubule dynamics and cre…
Microtubule plus end tracking proteins are a group of factors that accumulate specifically at the ends of growing microtubules where they control microtubule dynamics and the interactions with different structures, such as mitotic kinetochores, actin cytoskeleton and the cell cortex.
The core components of the microtubule plus end tracking machinery are End Binding (EB) proteins, such as EB1, which autonomously track the growing ends of microtubules and recruit to microtubule tips multiple funct…
UNIVERSITEIT UTRECHT
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