CORDIS Project
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This project investigates how cells detect and respond to the rigidity of their surrounding matrix, which is crucial for processes like differentiation and cancer progression. By analyzing fibroblast mechanosensing mechanisms, it aims to uncover the molecular pathways involved in rigidity sensing.
Recent studies show that the rigidity of the extracellular matrix is a critical determinant of cell growth, differentiation, and death.
Cells sense rigidity via integrin adhesions and respond by changing their morphology, signaling, and gene expression patterns.
Irregular rigidity signals or defective responses to appropriate rigidity signals underlie many medical disorders.
This is especially evident in cancer, where the ability of cells to detect differences in matrix rigidity is fundamentally…
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Israel, Tel Aviv
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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