CORDIS Project
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This project investigates how natural immune cells, specifically natural killer cells and macrophages, recognize and eliminate senescent cells, which are linked to aging and cancer. By understanding these interactions, the research aims to uncover potential therapeutic strategies for improving health during aging and p…
Cellular senescence, a stable form of cell cycle arrest, is a mechanism limiting the proliferative potential of cells.
Recent studies demonstrate that cellular senescence imposes a potent barrier to tumorigenesis and contributes to the cytotoxicity of certain anticancer agents.
In addition to sites of persistent damage and precancerous lesions, senescent cells have also been observed in tissues of aged individuals and can contribute to decline of tissue function with age.
Therefore, mechanisms r…
WEIZMANN INSTITUTE OF SCIENCE
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