CORDIS Project
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This project investigates the role of human guanylate binding protein-1 in regulating inflammation and its potential as a cancer prognostic factor. The research aims to characterize its secretion mechanisms and biological effects, with the long-term goal of developing therapeutic applications for cancer treatment.
The human guanylate binding protein-1 (hGBP-1) characterizes inflammatory cytokine (IC)-activated blood vessel endothelial cells (EC) and regulates the antiangiogenic activity of IC in these cells in vitro and in vivo.
In addition, hGBP-1 is the first GTPase which has been observed to be secreted.
In colorectal carcinoma, the expression of hGBP-1 in the tumour stroma has been shown in a recent work to be an independent prognostic factor associated with a better outcome.
The project focuses on th…
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG
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