CORDIS Project
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This project investigates how skeletal muscle adapts to exercise by studying novel transcriptional coactivators that regulate gene networks. By analyzing these mechanisms, the research aims to understand muscle's role in combating obesity, type 2 diabetes, and sarcopenia, ultimately contributing to new therapeutic stra…
Sedentary lifestyles have led to the increase of obesity, type 2 diabetes, and sarcopenia (decreased muscle mass) of the elderly.
Skeletal muscle plays a key role in these conditions, and it is clear that exercise can be as effective as medication in treating some of these ailments.
The adaptation of muscle to exercise involves the coordinated regulation of gene networks, whose products adapt muscle function to new challenges (e.g. increased contractility or oxidative capacity).
We have identifi…
KAROLINSKA INSTITUTET
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