CORDIS Project
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This project investigates the mechanisms controlling stem cell proliferation and senescence in the adult brain, particularly focusing on neural stem cells. It aims to understand how these processes decline with age and how they can be modulated to enhance neurogenesis after brain damage.
Stem cell self-renewal is a consequence of the ability to proliferate indefinitely while maintaining pluripotency.
In the adult brain, neural stem cells continuously produce neurons, and its importance for memory and repair after neurodegeneration and brain damage has been extensively investigated.
However, adult neurogenesis is limited and significantly decreases throughout life.
With aging, increased senescence greatly restrains the neurogenic potential of aged stem cells.
Senescence induction…
KAROLINSKA INSTITUTET
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